关于新药与治愈的希望

Treatments in development for psoriasis and/or psoriatic arthritis Compiled and updated January 2008 NameCompanyDelivery MechanismMechanism of ActionPhaseIndication CNTO 1275 Centocor, Inc. injectable IL-12/ IL-23 inhibitor Filed for FDA approval psoriasis Etanercept (Enbrel) Amgen, Inc injectable TNF-alpha inhibitor Filed for FDA approval pediatric psoriasis Taclonex gel Warner Chilcott topical gel Vitamin D analog, topical steroid Filed for FDA approval psoriasis ABT874 Abbott Immunology injectable IL-12/ IL-23 inhibitor III psoriasis BG-12 Biogen Idec oral fumaric acid ester III psoriasis CNTO 148 (golimumab) Centocor, Inc. injectable TNF-alpha inhibitor III psoriatic arthritis Fumaderm Biogen Idec oral fumaric acid ester III psoriasis ISA 247 Isotechnika oral anti-inflammatory agent III psoriasis Tacrolimus Astellas topical IL-2 and T-lymphocite inhibitor III psoriasis AS210 (Psoraxine ) Astralis, LTD. injectable anti-inflammatory agent II psoriasis Becocalcidiol (Asord) QuatRx Pharmaceuticals Co. topical Vitamin D analog II psoriasis Bimosiamose Revotar BioPharmaceuticals AG topical Cell migration inhibitor II psoriasis BMS-582949 Bristol-Myers Squibb oral anti-inflammatory agent II psoriasis Calcitriol Galderma topical Active form of Vitamin D II psoriasis CC-10004 Celgene oral TNF-alpha inhibitor II psoriasis CEP-701 Cephalon oral anti-inflammatory agent II psoriasis Certolizumab (Cimzia) UCB injectable TNF-alpha inhibitor II psoriasis CH-1504 Chelsea Therapeutics International, Ltd. oral anti-inflammatory agent II psoriasis CNTO 1275 Centocor, Inc. injectable IL-12/ IL-23 inhibitor II psoriatic arthritis CTA018 Cytochroma Inc topical Vitamin D analog II psoriasis CTAR398 Cytochroma Inc topical Vitamin D analog II psoriasis INCB18424 Incyte Corporation topical JAK inhibitor II psoriasis MM-093 Merrimack Pharmaceuticals oral anti-inflammatory agent II psoriasis PH-10 Provectus Pharmaceutical topical II psoriasis Rambazole Barrier Therapeutics oral retinoid II psoriasis RWJ-445380 Alza Corporation oral anti-inflammatory agent II psoriasis Recent approvals Adalimumab (Humira) Abbott Immunology injectable TNF-alpha inhibitor Approved psoriasis

[此贴子已经被作者于2008-3-28 11:38:02编辑过]

看看 type="submit"/>

看不懂撒，哪个翻译一下咯。

一层楼主发的英文看不懂啊,我想这里大多数人都看不懂,还是不要发英文的好,你要真让病友看,那就给翻译一下吧,先谢了

去铁疗或195泡温泉吧除了这我觉得没什么很有效了.

Treatments in development for psoriasis and/or psoriatic arthritis Compiled and updated January 2008 Name Company Delivery Mechanism Mechanism of Action Phase Indication CNTO 1275 "Centocor, Inc." injectable IL-12/ IL-23 inhibitor Filed for FDA approval psoriasis Etanercept (Enbrel) "Amgen, Inc" injectable TNF-alpha inhibitor Filed for FDA approval pediatric psoriasis Taclonex gel Warner Chilcott topical gel "Vitamin D analog, topical steroid" Filed for FDA approval psoriasis ABT874 Abbott Immunology injectable IL-12/ IL-23 inhibitor III psoriasis BG-12 Biogen Idec oral fumaric acid ester III psoriasis CNTO 148 (golimumab) "Centocor, Inc." injectable TNF-alpha inhibitor III psoriatic arthritis Fumaderm Biogen Idec oral fumaric acid ester III psoriasis ISA 247 Isotechnika oral anti-inflammatory agent III psoriasis Tacrolimus Astellas topical IL-2 and T-lymphocite inhibitor III psoriasis AS210 (Psoraxine ) "Astralis, LTD." injectable anti-inflammatory agent II psoriasis Becocalcidiol (Asord) QuatRx Pharmaceuticals Co. topical Vitamin D analog II psoriasis Bimosiamose Revotar BioPharmaceuticals AG topical Cell migration inhibitor II psoriasis BMS-582949 Bristol-Myers Squibb oral anti-inflammatory agent II psoriasis Calcitriol Galderma topical Active form of Vitamin D II psoriasis CC-10004 Celgene oral TNF-alpha inhibitor II psoriasis CEP-701 Cephalon oral anti-inflammatory agent II psoriasis Certolizumab (Cimzia) UCB injectable TNF-alpha inhibitor II psoriasis CH-1504 "Chelsea Therapeutics International, Ltd." oral anti-inflammatory agent II psoriasis CNTO 1275 "Centocor, Inc." injectable IL-12/ IL-23 inhibitor II psoriatic arthritis CTA018 Cytochroma Inc topical Vitamin D analog II psoriasis CTAR398 Cytochroma Inc topical Vitamin D analog II psoriasis INCB18424 Incyte Corporation topical JAK inhibitor II psoriasis MM-093 Merrimack Pharmaceuticals oral anti-inflammatory agent II psoriasis PH-10 Provectus Pharmaceutical topical II psoriasis Rambazole Barrier Therapeutics oral retinoid II psoriasis RWJ-445380 Alza Corporation oral anti-inflammatory agent II psoriasis Recent approvals Adalimumab (Humira) Abbott Immunology injectable TNF-alpha inhibitor Approved psoriasis

格式搞不好,抱歉上面是在http://www.psoriasis.org/research/pipeline/chart.php看到的,都是正在研究的新药,这里有没有医生,能够给大家讲讲,这些新药有没有预计可以治愈P的?如果没有,那有没有疗效很好,副作用很小的? 谢谢了先. 又及,我是脓疱型的,全身面积80%左右,现在下床都很困难了!

LZ貌似P的很厉害啊、、、

最近天气多变，自己更要小心哦！～

ENBREL 是DNA技术制造的一种蛋白, 它模拟了TNF(肿瘤坏死因子)在细胞上的接受器. 它是第三种在澳洲被接受用于银屑病治疗的生物制剂. 它通过与TNF分子结合从而阻止了TNF被激活继而于免疫细胞结合并产生炎症反应. ENBREL被用于中到重度的风湿性关节炎的儿童和成年人, 和进行性银屑病关节炎的成年人,僵硬性脊椎炎的成年人和斑块型银屑病的成年人. 2项研究显示 对于银屑病关节炎病人 改善了症状和抑制了疾病的发展.对于中重度银屑病病人, 皮肤症状的改善在用药12-24周后可以观察到,the effectiveness of ENBREL was first demonstrated in rheumatoid arthritis and clinical response has been maintained with treatment for up to five years. (不好意思, 我怕我翻译这句的意思有误差,所以就原文打进来.)

ENBRAL最常见的付作用 是在注射部位皮肤的中度反应, 多数在几天后自然消退,发生率在3分之1. 它被应用在风湿性关节炎已经多年,在对2000多病例长期随访中显示因为感染而需要抗生素和住院治疗的人数和应用安慰剂的比率相仿. 然而严重感染,特别是结核,血象和神经系统异常也有发生, 所以及时报告医生任何异常的症状.大约10分之一的人群会产生抗体,从而使治疗的有效率降低或者需要更长治疗时间. 注射部位皮肤反应包括 红斑, 痒, 痛, 肿胀. 另外 有些病人会在上一次注射部位和新注射同时发生皮肤反应.

来源说明,因为我的P发的厉害这次, 所以我被收到day dermertology unit治疗, 这是医院给我的一本材料上面有专门介绍在澳洲被应用的生物制剂,(我现在澳洲) 刚好看到有这个LZ文章中提到的药物, 所以我就试把它翻译了发上来. 另外, 书中还写到 生物制剂是治疗中到重度银屑病的发展方向,但对于各个不同制剂安全性还需要长期深入的研究. 个人觉得 一般我们是先试传统的治疗方法, 象外用药物, 光疗,洗浴等, 没有其他好办法下, 权衡利弊再使用.

祝楼主早日康复!

[此贴子已经被作者于2008-3-31 18:50:49编辑过]

[BR]非常感谢各位的关心!我现在在吃阿罗神,好些了.全身的脓包基本上没了,转成寻常的了.就是面积太大.我已经好多年夏天没有穿过短袖了.哎1！
[BR]请问yan79,在澳洲听说或了解到有什么最新的医学进展吗?乐观的估计多少年后可以有治愈的可能?