得肤宝治疗头皮银屑病---专业文献

Successful treatment of scalp psoriasis with Dovobet? ointment
使用得肤宝成功治疗头皮银屑病

Emerson R M, Howlett C 
Br J Dermatol 2004; 151(Suppl. 68): 52-53
       Scalp psoriasis is a common problem in the general population and many patients experience both psychological and social embarrassment (van de Kerkhof PCM, de Hoop D, de Korte J, Kuipers MV. Scalp psoriasis, clinical presentations and therapeutic management. Dermatology 1998; 197: 326–34). A range of topical treatments is available, and treatments are often used in combination. Despite this, many patients suffer from suboptimal disease control.
Dovobet ointment (Leo, Princes Risborough, U.K.; calcipotriol 50 microg g-1 and betamethasone dipropionate 0.5 mg g-1) has shown good efficacy in the treatment of body psoriasis (Kaufmann R, Bibby AJ, Bissonnette R et al. A new calcipotriol ? betamethasone dipropionate formulation (Daivobet?) is an effective once-daily treatment for psoriasis vulgaris. Dermatology 2002; 205: 389–93) but is not licensed for use on the scalp. We undertook an observational, uncontrolled, pilot study on the effectiveness of Dovobet ointment in the treatment of scalp psoriasis.
Nine patients with scalp psoriasis were enrolled. All patients had been referred to secondary care having failed on one or more topical preparations prescribed by their general practitioner. Their mean age was 36 years, and mean duration of scalp psoriasis 8?6 years. Patients were graded for extent of scalp involvement (0–100%), itch (10-point scale), plaque thickness and scaliness (very severe, severe, moderate, mild and very mild). Assessments were made before treatment, at 1 week, and 4 weeks after starting treatment. Patients were also asked to assess the overall response to treatment at follow-up. Before treatment, seven were recorded as having very severe ? severe plaque thickness, eight very severe ? severe scaliness, and seven had > 50% scalp involvement. All patients applied Dovobet ointment at 18.00–19.00 h each evening and washed it out 4 h later, for a total duration of 4 weeks. After 1 week, six patients achieved marked improvement of their scalp psoriasis with decreased levels of itch, a reduction in disease extent (only two patients >50% surface area involvement), reduced plaque thickness and scaliness. By 4 weeks, seven patients reported marked overall improvement, one patient slight improvement and one patient failed to attend for assessment (telephone enquiry demonstrated lack of efficacy of therapy). Compliance with treatment was excellent; however, patients reported that the ointment made the hair very greasy, and was difficult to wash out.
In conclusion, this is the first study to suggest that Dovobet ointment is an effective treatment for scalp psoriasis.

翻译如下：
头皮银屑病是普通人群中的常见病，患者因此身心受累。现在有大量药物可用于治疗头皮银屑病，但通常医生会使用联合治疗。尽管如此，患者仍然对疾病的控制不大满意。

得肤宝，丹麦利奥出品，卡泊三醇和倍他米松的复方制剂，一天一次使用，在治疗身体银屑病方面已经被证实具有高疗效。但是，得肤宝没有获得治疗头皮银屑病的许可。我们做了一项观察性的，非控制的样本化研究，来观察得肤宝治疗头皮银屑病的疗效。

9个头皮银屑病患者参与此次研究，他们都是过去使用一种或者多种外用药物治疗头皮银屑病失败后再次就医的患者，平均年龄36岁，平均患病时间是8.6年，患者根据头皮受累面积，瘙痒，斑块厚度以及鳞屑程度（非常严重，严重，中度，轻微，非常轻微）进行评级。对他们的评估分3次进行，治疗前，治疗一周和治疗4周后进行，患者同样被要求完整地反馈治疗各个阶段中的反应。治疗前，7个患者记录有非常严重和严重的厚斑块，8个记录有非常严重和严重的鳞屑，7人累及超过一半的头皮面积。所有的患者都在晚上6点-7点之间使用得肤宝一次，4小时后洗掉，这样持续4周。一周后，6个患者达到明显的治疗效果--他们瘙痒减轻，累及头皮的面积减小（仅有2个患者依然类及超过1半的头皮），斑块变薄，鳞屑减少。4周后，7个患者达到所有方面显著的改善，一个患者轻微改善，一个患者没有报告（电话跟踪后证实因缺乏疗效，他放弃治疗）。患者们对治疗的依从性非常好，但是患者反馈，软膏的使用使头发非常油腻，很难洗掉。

综上所述，这是第一个研究得肤宝用于头皮银屑病治疗的研究，同时建议，得肤宝是治疗头皮银屑病的有效选择。

 德芙宝贵呀，什么时候入医保就好啦、

达兄辛苦了，你要多促成这个要进医保啊。

现在门慢，这个得肤宝都是自费得。 门慢国家给的钱都用不上郁闷。

达力士可以。

　　请问什么是头皮银屑病？专指头上有Ｐ，而身体的其它部位没有Ｐ吗？
　　得肤宝不能用医保而且比较难买到，就是达力士搽剂都比较少，上次我去广州的华侨医院都没有搽剂，达力士搽剂入医保或公疗吗？

[此贴子已经被作者于2011-11-23 10:47:30编辑过]

QUOTE:

以下是引用风飞舞在2011-11-23 10:42:00的发言：
　　请问什么是头皮银屑病？专指头上有Ｐ，而身体的其它部位没有Ｐ吗？

头皮银屑病是指头上的P ，身体其他部位有和没有，只要头上有P ，那么头上的P就叫头皮银屑病，

头部一直是困扰着我，真难受

 什么时候全民免费医保就好了，从此不再为生病担忧、